Financial Statements and the Monetary Situation of Morrisons Essay

Financial Statements and the Monetary Situation of Morrisons - Essay Example The report is aimed towards guiding interested shareholders to rationally invest in Morrisons Supermarkets. Morrisons is one of the largest chains of supermarkets located in the U.K. The firm has their headquarters located in Bradford, England. Morrisons is counted amongst the big four supermarkets in the U.K, after Tesco, Sainsbury, and Asda. Currently, the company holds approximately 11% market share in the supermarket sector of the U.K. The company had initially begun as retailers of butter and egg in the year 1899. However, the firm has remained successful in expanding itself and presently it has 515 superstores and 113 local stores spread across the U.K, England, Wales, and Scotland. The U.K supermarkets are highly competitive and also possess the ability to earn a very high level of revenues. Consumers, in general, are seen to gain benefits from such high competition as they are able to procure goods and services at reduced prices. The purpose of the paper is to understand how analysis of financial statements facilitates better investments decision making. Income statements are prepared to estimate the level of profitability existing in a firm. They also indicate the efficiency with which an organization performs and earns revenue. Investments decisions are crucial as they may either cause a shareholder to earn adequate profits or lose earnings on the capital invested. Shareholders face the risk of losing their savings if financial statement interpretations are not carried out effectively. The income statement is essentially a summary of the incomes and expenses of a firm presented in a summarised form for a particular period. By analyzing the incomes, expenses and the profits of a number of years, investors can understand how effectively a firm manages their internal operating expenses so as to earn sufficient profits.

Diminishing American Pride Essay Example for Free

Diminishing American Pride Essay The book Zeitoun basically talks about a Syrian American family’s experience in the time of Hurricane Katrina. It was mainly divided into two story lines, one of Abdulrahman Zeitoun, the main character, a Syrian American contractor; and one of Kathy, his wife, a white woman converted Muslim. Zeitoun had an extraordinary life, also an extraordinary experience in the time of Hurricane Katrina. He was a successful well-known businessman in local area. When everyone else was fleeing their hometown before Katrina came, Zeitoun chose to stay to protect his house and business. Later then when the city was flooded, he travelled around with his small canoe, delivering help and resources. However, he was wrong arrested as a looting suspect then and was sent into jail. He was treated as a terrorist and taken away the right of fair trial, forced to confine in a maximum security prison for a crime he didn’t commit. At the end, Zeitoun was released and able to unite with his family again, but he was not compensated in any ways for his misfortune. As this book describes, everything in the time of Hurricane Katrina had gone crazy, including the American criminal justice system. The main objection of this book is to criticize racism phenomenon in America and the rotten criminal justice system. Racism is a main subject in this book. It was first mentioned in this book in Kathy’s story line about her past life experience. â€Å"Years earlier, Kathy and her mother had gone to the DMV together to have Kathy’s license renewed. Kathy was wearing her hijab, and had already received a healthy number of suspicious looks from DMV customers and staff by the time she sat down to have her picture taken. The employee behind the camera did not disguise her contempt. ‘Take that thing off,’ the woman said. † (Zeitoun page 58) From the mentioning of these kinds of past experience seemed irrelevant to Hurricane Katrina, we can see the author’s desire to insert the topic of racism into this book. Kathy’s case shrinks small comparing to Zeitoun’s case in his arrest. â€Å"‘You guys are al Qaeda,’ the soldier said. Todd laughed derisively, but Zeitoun was startled. He could not have heard right. Zeitoun had long feared this day would come. Each of the few times he had been pulled over for a traffic violation, he knew the possibility existed that he would be harassed, misunderstood, suspected of shadowy dealing that might bloom in the imagination of any given police officer. After 9/11, he and Kathy knew that many imaginations had run amok, that the introduction of the idea of ‘sleeper cells’- groups of would-be terrorists living in the U. S. and waiting, for years or decades, to strike- meant that everyone at their mosque, or the entire mosque itself, might be waiting for instructions from their presumed leaders in the hills of Afghanistan or Pakistan. (Zeitoun page 212) It didn’t surprise me at all that Zeitoun have those thoughts that might seem over-worried in some people’s eyes.. Indeed, another author Maysan Haydar had mentioned similar thoughts in her essay â€Å"Veiled Intentions: Don’t Judge a Muslim Girl by Her Covering. † â€Å"Now some people hold their breath a bit longer, assuming I’m a fundamentalist or wondering if I’m there to cause them harm. I sense people studying me on the trains, reading the cover of the book in my hand and trying to gauge if I am one of ‘us’ or one of ‘them’. I grapple with the frustration that I can’t reassure everyone individually that my goals have everything to do with social justice and nothing to do with holy war. But I have seen suspicious fade in the eyes of the pregnant woman to whom I’ve given my subway seat or the Hasidic man whose elbow I’ve taken to help him up the stairs. † (Haydar pg 406) I feel very sorry for Haydar and Zeitoun’s experiences. Muslim people are always feared to be presumed as terrorist. American frightened by the traumatic event of 9-11 developed a stereotype against people from Middle East. The fear of being attack also again drove American crazy on national security. However, for whatever reason, racism has put upon so much harm on people we discriminate against. Muslim people like Zeitoun, hard working and honest people, are forced to live under the fear of being prosecuted for his race someday, taken away from his family, locked up in somewhere nobody would know he’s died or not. Those fears have made them coward under a lowly skin, live like second-class citizens. â€Å"In the weeks after the attacks on the Twin Towers, Kathy saw very few Muslim women in public. She was certain they were hiding, leaving home only when necessary. In Late September, she was in Walgreens when she finally saw a woman in a hijab. She ran to her. ‘Salaam alaikum! ’ she said, taking the woman’s hands. The woman, a doctor studying at Tulane, had been feeling the same way, like an exile in her own country, and they laughed at how delirious they were to see each other. † (Zeitoun page 46) Indeed, as part of international society, American allowed people to be exiled from their own country. In Edward Said’s essay, â€Å"States†, he escribed how they, Palestinian people was exiled from their own country and forced to scatter around the world, be denied of personal identity everywhere. †Some Israeli settlers on the West Bank say: ‘The Palestinians can stay here, with no rights, as resident aliens. ’ Other Israelis are less kind. † (Said pg 546) â€Å"The fact is that today I can neither return to the places of my youth, nor voyage freely in the countries and places that mean the most to me, nor feel safe from arrest or violence even in the countries I used to frequent but whose governments and policies have changed radically in recent times. (Said pg 547) In a documentary I have watched, in some cases, if a Palestinian wants to travel from points to points, they have to go through checkpoints set up by local military. They would be asked to show their prove of identity and relevant documents which sources were mostly denied. Nobody tell them what to do then, no laws protect them, some of them can’t even go to hospitals and schools like every other human being in the course that they don’t have a legal identity. We as adults, teach our kids not to bully in school, that it’s wrong to do so. In contrast, as a human, we allow our country, ourselves to bully on people with a different skin tone. Isn’t this hilarious? Another main subject posted in this book is the criminal justice system in America. Zeitoun was initially arrested in his house, then taken to the bus station, naked searched and put in jail. Throughout the whole process, he had never been told of his charges, no phone calls granted, no one had ever given him a chance to defend himself or to find a lawyer. He was treated as terrorist. In the course of his Middle-Eastern accent, everything about him seemed suspicious to the guards. He was kept in inhumane confinement, was given pork for food despite his religion. He had a deep wound in his feet but was never treated nor given any medical attention. There were basically no laws in effect, Zeitoun was treated as if he wasn’t an American citizen anymore, constitutions and laws don’t protect him. â€Å"Watching the evidence on the table mount, Zeitoun’s shoulders slackened. Most municipal systems were not functioning. There were no lawyers in the station, no judges. They would not talk their way out of this. The police and soldiers in the room were too worked up, and the evidence was too intriguing. (Zeitoun 215) But the most disappointing fact about this is what t I found out later in the book, that all of this happened to Zeitoun was not special cases happened once or twice, it was somehow permitted. â€Å"But knowing that Zeitoun’s ordeal was caused instead by systemic ignorance and malfunction- and perhaps long-festering paranoia on the part of the National Guard and whatever other agencies were involved-was unsettling. It said, quite clearly, that this wasn’t a case of a bad apple or two in the barrel. The barrel itself was rotten. (Zeitoun 307) This is totally different from what I learnt from my administration of justice class. The whole process is wrong. How could an innocent person be justified this way? Not even a phone call allowed. It is nothing better than abduction. Who gave government the right to treat people like this? I guess under the name of National Security, there’s nothing government can’t do, all laws and constitutions could be undermined. James Bamford, author of essay â€Å"Wired† pointed out the same point, says in his essay, â€Å"’They violated the Constitution setting it up. He says bluntly. â€Å"But they d idn’t care. They were going to do it anyway, and they were going to crucify anyone who stood in the way. ’† â€Å"Basically all rules were thrown out the window, and they would use any excuse to justify a waiver to spy on Americans. † (Wired pg 0843,, 084) National Security, initially served the principle of protecting Americans has become a tool to against Americans. â€Å"The NSA has turned its surveillance apparatus on the US and its citizens. It has established listening posts throughout the nation to collect and sift through billions of email messages and phone calls, whether they originate within the country or overseas. It has created a supercomputer of almost unimaginable speed to look for patterns and unscramble codes. Finally, the agency has begun building a place to store all the trillions of words and thoughts and whispers captured in its electronic net. † (Wired pg 81) Isn’t it scary to know our government has already gone this far for â€Å"National Security†? Anyone is a target of NSA. But who is more prone to be checked on? I believe this could be linked again to the topic of racism. Look back to Zeitoun and his fellows’ arrest; I believe they would never have been presumed as terrorists, despite the same context and evidence, if all four of them are white. The book Zeitoun serves more than a journalism. Dave Egger cleverly brought out these two important topics to us through the book. Could we still call our country States of freedom and equality after learning all these previously unknown facts? It’s time for people to stand up to protect the prides of America, fix our criminal justice system, drive racism into history and look forward to a better, true States of freedom and equality.

Effect of Estrogen on Osteoclasts and Osteoblasts

Effect of Estrogen on Osteoclasts and Osteoblasts Osteoporosis is a disease that afflicts many people, especially women. This disease is very debilitating and is characterized by excessive bone loss which results in severe fractures. There are two types of osteoporosis: Type I and Type II. Type I is the more severe type and is prevalent in post-menopausal women. There have been numerous hypothesis and studies as to the cause of osteoporosis and its relation to menopause (Riggs, 2002). The findings suggest that estrogen plays a major role. Estrogen receptors have been identified in bone and are involved in the production and maintenance of both osteoclasts and osteoblasts (Eriksen, 1988; Girasole, 1992). Osteoclasts function in bone resorption, and osteoblasts function in synthesizing new bone, hence these two cell types have opposite effects on bone (Saladin, 2010). Studies have shown that a decrease in estrogen levels in post-menopausal women is the primary cause of this reduction in bone density (Girasole 1992; Menolagas, 2002). Estrogen is a steroid hormone that has many different functions. It is primarily involved in sexual differentiation and maturation, but also has some less obvious effects including thermoregulation and the maintenance of bone mineral deposition. Estrogen is a lipophilic hormone and therefore is capable of diffusing through the cell membrane and binding its two intracellular receptors, ERÃŽ ± and ERÃŽ ² There are three female sex hormones: estrone (E1), estradiol (E2) and estriol (E3), however, estrogen is the common name used to refer to all three, though estradiol is the main form of estrogen (Carlsten, 2005). Estrogen is mainly synthesized in the ovaries, though its synthesis is not limited to the ovaries. Some peripheral tissues, such as adipose tissue, are capable of producing estrogen by way of steroid precursors (Nelson, 2001; Simpson 1981). Synthesis of estrogen involves many different precursors the first of which is cholesterol. Cholesterol is converted in the ovarian follicle to pregnenolone which can be converted to 17ÃŽ ±-hydroxypregnenolone. 17 ÃŽ ±-hydroxypregnenolone is then converted to dehydroepiandrosterone which is converted to androstenedione which undergoes a conversion to the androgen, testosterone. Aromatase then converts testosterone to esradiol (E2). Estradiol is then secreted from the follicle and can either act on its target tissue or undergo another conversion to estrone (E1) and estriol (E3) which takes place in the liver. Estrogen has two main receptors ( ERÃŽ ± and ERÃŽ ²) that mediate its primary effects. These receptors belong to the nuclear receptor family and are transcription factors that are regulated by ligands (Carleson, 2005). Estrogen receptors require numerous coregulatory proteins that have cell-specific expressions. These cell specific expressions delineate some of the specific actions of estrogen in its various target tissues (Heldring, 2007).The two estrogen receptors maintain some highly conserved regions such as their DNA binding domains; both ERÃŽ ± and ERÃŽ ² bind the same DNA response elements. Other domains are not at all conserved, such as the amino-terminal which exhibits significant variability in sequence as well as in length. The ligand-binding domain is located at the C-terminal and is a multifunctional domain. Both the N-terminal and the C-terminal contain activation functions, AF-1 and Af-2, respectively. These activation functions, work to activate transcription by recru iting coregulatory proteins to the DNA-binding domain. Though ERÃŽ ± and ERÃŽ ² are fairly homologous, they are actually derived from separate genes which are located on separate chromosomes. ERÃŽ ± and ERÃŽ ² also give very different splice variants (Heldring, 2007). ERÃŽ ± and ERÃŽ ² regularaly act as antagonists of each other when expressed in the same cells; hence, estrogen signaling functions as a balance between these two contradictory receptors (Carleson, 2005). It appears as if ERÃŽ ² works to inhibit the effect of ERÃŽ ± by not only altering the recruitment of transcription factors essential for of ERÃŽ ±-dependent transcription, but also by increasing the degredation of ERÃŽ ± by way of ERÃŽ ²2, a splice variant of ERÃŽ ² (Heldring, 2007). Estrogen receptors have been found in many non-reproductive tissues including bone. This fact lends credence to the theory of estrogens involvement in the maintenance of bone. Estrogen Signaling There are a few distinct pathways that are involved in estrogen signaling. Three of these signaling pathways are ligand-dependent, the fourth is ligand-independent. The first ligand-dependent pathway is the classical or direct pathway (Fig. 1a.) in which the ligand (usually estradiol) binds the receptor and this ligand receptor complex then dimerizes with another ligand-receptor complex in order to bind estrogen response elements in the promoters of target genes (Carleston, 2005). The second ligand-dependent pathway is referred to as the tethered pathway (Fig. 1b.). The tethered pathway involves protein-protein interactions with transcription factors. These interactions occur after the receptor has been activated by the ligand. Hence, the receptor activates transcription by an indirect DNA binding mechanism (Carleston, 2005). The non-genomic pathway (Fig 1c.) is also ligand-dependent but is not as well understood as the previous two. It is known that the receptor is activated by the ligand, which then initiates a signaling cascade resulting in the activation of second messenger systems (Heldring, 2007). Studies have shown that the activation of these second messenger systems display some common effects including an increase in the production of cAMP levels as well as the activation of the MAPK pathway (Lim, 2006). This activation of second messenger systems ultimately leads to a rapid physiological response without involving gene regulation (Heldring, 2007). The fourth signaling pathway is ligand-independent (Fig.1d.) and involves activation by way of other signaling pathways such as that of Growth Hormone which ultimately leads to the activation of gene regulation. This activation of gene regulation occurs due to the activation of protein kinases that work to phosphorylate the estrogen receptor. This phosphorylation causes receptor dimerization which allows the receptors to then bind the DNA and activate gene transcription (Carleson, 2005; Heldring, 2007). a.) The direct ligand dependent pathway in which the ligand directly binds the receptor which dimerizes and binds the DNA promoter region. b.) The tethered pathway is indirect and involves protein interactions with transcription factors that allow for the binding of the transcription factor to the promoter region c.) The non-genomic pathway involvs activation by the ligand which then can cause a signal transduction pathway resulting in activation of second-messenger systems. d.) The ligand-independent pathwayin which activation occurs by other signalling pathways (i.e. GH) and eventually leads to activation of gene transcription. Source: Heldring, Pike, Andersson et al. Estrogen Receptors: How do they signal and What are Their Targets. Physiol. Rev. 87: 905-931. 2007. Estrogen and Osteoporosis Osteoporosis is a disease that is characterized by a decrease in bone mineral density and hence an increase in the frequency of bone fractures (Though osteoporosis is often associated with post-menopausal women, the disease is not necessarily limited by gender. Osteoporosis was separated into two classes in 1983 by Riggs and Melton. The two types of osteoporosis (Type I and Type II) differ in regions of bone mineral density, patterns of fracture, causal mechanisms and hormonal changes. Type I osteoporosis is the more severe form of osteoporosis, however, type II is more common especially in the elderly (70+) (Riggs, 2003). Type I Osteoporosis is prevalent in post-menopausal women. It usually arises within 20 years after menopause and is associated with excessive cancellous bone loss. Fractures occur at sites that are rich in cancellous bone. Type I osteoporosis is associated with an increase in osteoclast function and a decrease in osteoblast function. This is thought to be due to a decrease in the levels of estrogen present in post-menopausal women (Girasole, 1992; Ribot, 1997). Osteoporosis has been found to occur in men also; primarily elderly men. The underlying explanation for osteoporosis is that the sex steroids play a role in the remodeling process of bones. Hence, when ovarian function ceases due to menopause in women, estrogen levels decrease and bone remodeling is therefore disrupted in a deleterious fashion. Osteoporosis in men is associated with a loss of androgens which is generally due to either castration or aging (Manolagas, 2002). Type II osteoporosis is prevalent in both men and women and can occur at any age, though it is more often associated with the elderly (above age 70). Type II osteoporosis is characterized by the loss of trabecular bone. It is generally due to aging effects such as hyperparathyroidism and impaired bone formation, and also a decrease in vitamin D and PTH levels. There is some speculation as to whether or not Type II osteoporosis may also be due to late effects of decreased estrogen levels (Riggs, 2003). Evidence for estrogens involvement in osteoporosis and its actions on maintaining bone mass can be seen in the study conducted by Riggs et al. which involved 36 women with vertebral fractures due to type I osteoporosis. These women all displayed a high bone turnover rate. The women with type I osteoporosis were compared with 36 normal women (women who did not exhibit Type I osteoporosis) after they were given small amounts of the sex steroids: estradiol, estrone, and testosterone. Blood and urine samples were continuously taken (about every 24 hours) and analyzed to reveal that the levels of the sex steroids were equally apparent in both groups of women. However, the amount of all bone biochemical markers (involved in bone turnover) appeared higher in the osteoporotic women. Though the experiment did not detect a difference in the sex steroid concentrations between the two groups of women, post-experimental power calculations were done to show that there are differences between the t wo groups when ÃŽ ± = .05 and 1-ÃŽ ² = 0.8. The differences for serum estrone, estradiol and testosterone were as follows: 6.3%, 9.9%, and 4.4%, respectively. Some of the women with osteoporosis then underwent another study in which they were split into two groups. One group of osteoporotic women received one-years worth of treatment with transdermal estrogen while the other group of osteoporotic women received a years worth of treatment with a placebo. The women who underwent estrogen treatment displayed a remarkably larger decrease in bone turnover markers than the women treated with the placebo (Riggs, 2002). Osteoclasts, Osteoblasts and the Estrogen Connection Osteoclasts are cells involved in maintaing bone homeostasis and are located on the bone surface in the anterior portion where they work to digest old bone (Manolagas, 2002). Osteoclasts are derived from macrophages, and are very large multinuclear cells formed from the fusion of multiple stem cells (Saladin, 2010). Osteoclasts function in digesting bone; hence they are involved in bone resorption. Bone resorption is a process that releases calcium back into the circulatory system by digesting bone tissue (Saladin, 2010). The function of osteoclasts is essential to the broader process of bone remodeling. Osteoblasts are also involved in maintaining bone homeostasis and are active in the process of bone remodeling. Osteoblasts are located in the posterior portion of the bone surface and work to produce new bone in the areas that underwent excavation by osteoclasts (Manolagas, 2002). Osteoblasts are derived from mesenchymal stem cells (Zallone, 2006). The mesenchymal stem cells give rise to osteogenic cells which give rise to most other bone cell types including osteoblasts. Osteoblasts are immature bone cells that are located beneath the endosteum and periosteum of the bone. Osteoblasts synthesize the components of the bone matrix. The matrix undergoes mineral deposition which causes it to harden, and hence the osteoblasts become trapped within the matrix. When osteoblasts mature, they become osteocytes which function in maintaining bone (Saladin, 2010). Osteoblasts function in making new bone. They deposit calcium salts into the bone matrix in order to make hydroxyapate which is the calcium reserve in bone. Osteoblasts fill in the cavities that were excavated by osteoclasts with new bone. Osteoblasts may be stimulated by various signals and hormones such as calcitonin and estrogen which both function in decreasing blood calcium levels and maintaining calcium levels in bone (Saladin, 2010). Estrogen receptors (ERÃŽ ± and ERÃŽ ²) as well as androgen receptors (AR) have been identified in both osteoblasts and osteoclasts and their parental cells. The presence of these receptors indicates that estrogen has a direct effect in mediating the process of bone remodeling (Eriksen, 1988; Girasole, 1992; Manolagas, 2002). Estrogen and androgens also have an indirect effect on the process of bone remodeling via the cytokine, interleukin-6 (IL-6) which is an important factor in the process osteoclastogenesis in bone marrow stromal cells (Carleston, 2005; Manolagas, 2002). The Study conducted by Girasole et al. has shown that estrogen has an inhibitory effect on IL-6, which results in a decrease in the production of osteoclasts. This decrease in osteoclastogenesis ultimately causes a decrease in bone resorption (Girasole, 1992). Estrogen and androgens inhibit the production of IL-6 in vitro by inhibiting Interleukin-1 (IL-1) and tumor-necrosis factor (TNF)-ÃŽ ±. IL-1 and TNF-ÃŽ ± are involved in the synthesis of IL-6 (Ribot, 1997). Some studies suggest that estrogen has more of an effect on TNF-mediated production of IL-6, than on IL-1 mediated production (Girasole et al. 1992). The expression of the IL-6 receptor subunits, gp130 and IL-6-RÃŽ ±, are also suppressed in bone marrow stromal cells and in osteoblast progenitor cells (Manolagas, 2002). Studies done in mice have shown that when the IL-6 gene is knocked out or neutralized (via antibodies) the upregulation of colony-forming unit-granulocyte/macrophage (CFU-GM) (which osteoclasts are derived from) in bone marrow is prevented. Hence, there is not an increase in osteoclast production. The results showed that the antigen caused the estradiol-induced inhibition of bone resorption to itself be inhibited (Ribot, 1997). A decrease in estrogen (as well as androgens) also has an effect on osteoblasts. One mechanism by which osteoblasts are regulated by estrogen can be observed in bipotential stromal cells; these cells express the estrogen receptors. The bipotential stromal cells are parents to both adipocytes and osteoblasts. A study conducted by Okazaki et al. in mouse bone marrow stromal cell lines, found that estrogen works to mediate the differentiation of the parental bipolar stromal cells towards the production of osteoblasts (Okazaki, 2002). Post-menopausal women who exhibit bone loss have been observed to have an increased amount of lipid concentration in their bone marrow. Hence, a decrease in estrogen would cause an increase in adipogenesis and a decrease in osteoblastogenesis (Okazaki, 2002). This decrease in osteoblastogenesis would result in a decrease in bone formation. Estrogen Replacement Therapy A study that was conducted on post-menopausal Chinese women by Sun et al. was also useful in determining the effects of estrogen treatment for osteoporosis. These women all ranged from 41-58 years of age and had undergone menopause for more than a year. The women were split into 4 different groups. Each group received different levels of 17ÃŽ ²-estradiol (E2) gel along with a form of progesterone, either micronized progesterone (MP) or medroxyprogesterone (MPA). The progesterone was added along with the estrogen in order to prevent endometrial hyperplasia which may occur as a result of estrogen replacement therapy. The dosages differed in both progesterone type and concentration as well as in estrogen concentration. The exact dosages for each group were as follows: group 1 received 1.5 mg E2 and 100 mg MP, group 2 received 1.5 mg E2 and 2 mg MPA, group 3 received 0.75 mg E2 and 100 mg MP, and group 4 received 0.75 mg of E2 and 2 mg MPA. These dosages were administered once a day, 25 days a month for at least a year (some of the subjects were studied for two or three years). Blood and urine samples were taken from these women and monitored for bone mineral density (BMD). The results showed that after about a year of this treatment, the average increase in BMD in cancellous bone of the 4 groups ranged from 4.6%6.4%. After 36 months an increase in the BMD of the bones in the neck and the lumbar vertebrae were observed; the averages ranged from 4.3%-7.5% and 4.2%-6.2%, respectively. This study also found that the BMD in the hip (an area that is prone to fractures), had significantly higher levels than the baseline levels. The main purpose of the study was to determine an appropriate dosage of estrogen and progestin for post-menopausal Chinese women; the results of the study indicated that either 0.75 mg or 1.5 mg of E2 daily is sufficient for prevention of bone loss in Chinese women. The study suggests that hormone replacement therapy has a significant effect on bo ne, especially during the first two years of treatment (Sun, 2002). The knowledge of estrogens actions on bone and the inhibitory effect it has on osteoclastogenesis, has led to the utilization of estrogen as a treatment for osteoporosis. Estrogens ability to maintain bone mass in post-menopausal women has made estrogen replacement therapy a valuable form of treatment. This treatment utilizes the protective properties of estrogen on bone and functions in increasing bone mineral density (BMD) in post-menopausal women (Sun, 2002). Estrogens positive effects on bone are amplified during the treatment; hence, estrogen induces stimulation of osteoblastogenesis and inhibits osteoclastogenesis via IL-6 (Girasole, 1992; Okazaki, 2002). The type of estrogen administered (other than estriol) seems to have no difference in effectiveness; hence, synthetic estrogen, 17ÃŽ ²-estridiol, and equine estrogen all have equal effects on the maintenance of bone mass and all work to decrease the amount of bone turnover (Ribot, 1997). The method by which estrogen is adminis tered (i.e. transdermally, percutaneously, etc.) also does not appear to make a difference in its effectiveness. The dosages of estrogen as well as the duration of the treatment seem to be the only variables involved in determining the effectiveness of estrogen replacement therapy (Ribot., 1997). In order for estrogen replacement therapy to have a long term effect, estrogen must be administered for about 5-7 years (Cauley 1995; Ribot, 1997). Estrogen replacement therapy is also most effective if it is initiated early after menopause. A study conducted by Cauley et al. found that women who started estrogen treatment within 5 years of menopause and/or underwent treatment for 10 years or more, had the most effective and long-lasting results (Cauley 1995). Though Estrogen Replacement Therapy is a promising and effective mechanism for treatment of osteoporosis, it is associated with some serious physiological risks. Long-term usage of estrogen has been known to cause endometrial cancers. However, when estrogen is administered in conjunction with progestins, the risk of endometrial hyperplasia is significantly reduced. (Ribot, 1997; Sun, 2002). Many studies have been conducted to determine whether or not there is a relationship between estrogen and breast cancer. Some studies suggest that there is a correlation between the risk of breast cancer and use of estrogen (Lim, 2006). Other studies suggest that there is no correlation (Ribot, 1997). Though estrogen replacement therapy is associated with a few serious risks, it also has other positive physiological effects on other areas of the body, not just bone. For example, estrogen is thought to have a preventive effect on Alzheimers disease and also on Coronary Heart Disease (CHD) in post-m enopausal women (Ribot, 1997; Tang, 1996). The onset of type I osteoporosis is generally characterized by a loss of ovarian function which therefore results in a loss of estrogen in postmenopausal women. (Manolagas 2002). Estrogen can be used as a treatment for osteoporosis due to the presence of estrogen receptors in osteoclasts, osteoblasts and their precursors, as well as in bone marrow stromal cells (Zallone, 2006). The positive actions of estrogen on bone are mainly due to the suppressive actions of estrogen on bone resorption by osteoclasts (Okazaki, 2002). When Estrogen levels are decreased, the normal regeneration process, which involves bone resorption followed by an appropriate amount of bone formation, is disturbed (Zallone, 2006). Various in vitro studies have been conducted that demonstrate that the presence of estrogen (as well as androgens) increases the action of factors that work to inhibit the process of osteoclastogenesis (Bellido, 1995). The decrease in the production of osteoclasts due to estrogen would t herefore cause a decrease in the process of bone resorption (Okazaki 2002). Estrogen also has an effect on the production and differentiation of osteoblastic cells. However, it has the opposite effect on osteoblasts and thereby stimulates their production by shifting the mechanism of bipolar stromal cells towards the production of osteoblastic cells rather than that of adipocytes (Okazaki, 2006). Hence, estrogen works to decrease bone resorption and increase bone formation, thereby creating a protective effect on bone which can be utilized to treat such debilitating diseases as osteoporosis.

The Corrruption Of Innocence :: essays research papers

The Corruption of Innocence   Ã‚  Ã‚  Ã‚  Ã‚  It has struck some leaving a lasting impact while others just let it go by. Some would see it as corruption, and others see everyday life. I see it as the pure loss of innocence in a world of corruption. This new issue has risen in today's generation leaving no one free of it wrath. This has not been the first we have seen of this. The loss of innocence has been referred to over years by many authors, but now we come to see it in our lives a lot more frequently. According to authors like Emerson and Salinger, who although wrote their pieces so far apart, feel everyday in life the American Character is faced upon with the corruption of innocence that takes away from their unique American Character.   Ã‚  Ã‚  Ã‚  Ã‚  In his book, The Catcher in the Rye, J.D. Salinger focuses on the theme of innocence for a large amount of time. Holden constantly refers to everyone as being a phony and that they had lost their innocence, which had been corrupted when they matured and were exposed to society. The society had exposed them to the real world and made them think in order to survive they must follow others. Holden goes in part of the book about jobs he likes and starts to describe job of a lawyer and says how they are sincere and try to save innocent lives, but then he goes on to think about how they are probably phonies and only doing it to be hot-shots and makes lots of money to impress society. (Salinger 172) The outcome of his thoughts was that everybody had conformed and followed each society's ideas, which upset Holden because no one was free of corruption accept the children of society, like Ally. Holden sees it as a major issue in the book and serves as a major role of Holden 's throughout the book. The issue even leads to the title of the book in the sense that it is named after his supposed job he wishes to under take as a Catcher in the Rye. He wants to be a catcher in a field of rye and little children who catches children from falling off the cliff and being corrupted by society. (Salinger 173) Therefore, in fact the theme of innocence has a significant role in this book.   Ã‚  Ã‚  Ã‚  Ã‚  Another author who also uses the role of innocence and corruption as a major theme is Ralph Waldo Emerson in his essay 'Self-Reliance';.

Increase in Young Criminals :: Argumentative Persuasive Papers

Increase in Young Criminals Increased youth crime rate is caused largely by absent fathers as a result of divorce made too easy. Consider this chilling forecast. When we pass the year 2000, we will see two groups of working age adults emerging. One group will have received psychological, social, economic, educational and moral benefits and the other group will have been denied them all. The first group will have grown up with a father present in the house and the second group will have not had a father present. The groups will be roughly equal in size. In order to be divorced in my parent's era of the fifties, one mate had to be proven adulterous. Legally, one party was deemed guilty and one was innocent. That finding affected each party financially and socially enough so that most couples tried hard not to divorce. In Canada the rate of divorce in 1951 was one out of twenty couples. In the late sixties, the "sexual revolution" began and couples rebelled against the constraints of marriage. Movie makers and journalists became rich extolling the virtues of free love and liberation. The addition of more grounds for divorce and the elimination of the need to appear in court made it easier for couples to split. Now there are "no fault" divorces which further decrease the stigma. By 1987 one out of two couples divorced. Since then, the annual divorce rate has dipped slightly. The stigma is almost gone. Books are written about doing your own divorce. One can obtain a low budget quickie divorce by phone or fax to the Dominican Republic in about three days. There are "divorce parties". Even the Royal Family discusses its divorce dilemmas on t.v. The divorce picture is not all rosy. According to sociologist Lenore Weitzman, divorced women get by on about 64% of the income they had during marriage. For their children, this translates into less money for school activities, clothes, opportunities for traveling and learning, day care and sometimes food. Children can be called on to do adult tasks before they are ready, like caring for younger siblings. Older children may be required to work long hours at a job to help bring money to the family. As a result, they may fall behind in their school work. After a while, the child may feel it is hopeless to try to keep up and decide to quit school.

Process Paper on Making Snowman

Daniel Ricciardi Man of Snow Jim woke up after a large snowstorm last night that left ten inches of snow. His nephew Sean ran in to jim’s room and asks him to go outside. Sean said no one wanted to go and if they did it was to shovel. Of course Jim would rather play in snow then shovel so he gets outside before he gets assigned to work. He asked Sean what his favorite activity was in the snow. Sean said sledding but he was more interested in something else he hasn’t done before, making a snowman. Jim couldn’t wait to show Sean how to build the perfect snowman so he begins right away.Now their snowman needs three main body parts his legs, chest, and head. To make each body part they mold a small ball of snow in their hands and place it on the ground. Then begin to roll the ball around allowing it to gather up snow gradually getting larger. Jim Made sure not to roll it in a straight line since it might end up with a soup can shape snowball. They made sure their fir st ball for the legs was as big as Sean. Now repeat the process of molding the ball and rolling it to create the three body parts with one large and the rest gradually getting smaller.Lifting the chest snowball onto the leg snowball was difficult considering the size of my snowballs but Jim managed. Now they have the legs, body, and head with a perfect size deduction going from legs to head. Sean was filled with so much excitement seeing this large snow creature in almost full form. Sean could have been completely satisfied with the snowman he was so big he could climb it. Jim mentions to Sean that there not finished, the poor guy has no face. Sean was puzzled on how to draw a face onto our snowman. Jim told him we will not draw but all you need is a dozen or so quarter sized stones.Sean offered right away to look for them. While he did that Jim went inside to get a large orange carrot for the nose. Jim was lucky enough to find 2 large buttons for the eyes and a few smaller ones for a button shirt. Jim runs outside to see Sean stuffing the stones creating a in a vertical line across the lower part of the head. Jim asks him if he wants the snowman to smile or keep this straight face. Without an answer Jim starts to align the stones into a happy face along with the eyes and nose and buttons down the body. Sean is laughing uncontrollably at the goofy looking face.Jim couldn’t help laughing as he walks to the woods. He finds two skinny branches as along as his own arm. He stabs both sides of the snowman body with the left one tilted up to look like a wave. Sean jumps up and gives him a high-five almost snapping the arm right off. Now for them to finally finish, they both go inside and look for a hat, scarf, and mittens. They got the most colorful and wacky styles they could find. Together they place the clothing on there now finished snowman. With Jims help Sean created his first most perfect snowman.

The Hurt Locker Leadership

Another OB theory that is examined in The Hurt Locker is Leadership. This theory is defined as the ability of an individual to influence, motivate, and enable others to contribute towards the effectiveness and success of organizations of which they are members. There are four perspectives on Leadership; these perspectives include Trait, Behavioral, Contingency and Transformational. The trait or competency perspective of leadership proposed that leaders are more likely to have certain personality, social, physical, or intellectual traits than non leaders. Trait perspective emphasis on leadership competencies, which are learned behaviors such as skill, abilities, and values. Successful leaders acquire competencies that include; * Drive and energy (includes achievement, motivation, ambition, tenacity, and initiative) * Leadership motivation (the desire to lead but not to seek power as an end in itself) * Honesty and integrity * Self-confidence (associated with emotional stability) * Cognitive ability * Knowledge of the business. Another component of Trait perspective is leadership agility, which is the ability to make wise and effective decisions amid complex changing conditions. The next leadership perspective is behavioral. This perspective proposes that effective leader behave in a certain desirable way. This behavior can be perceived as task-oriented, people oriented, neither, or both. A task-oriented style of leadership spells out duties and specific tasks, tells people what to do and how to do it, ensures employees follow rules, and encourages employees to reach peak performance. This style is also referred to as production-oriented and autocratic. On the other hand a people oriented or democratic style of leadership shows trust and respect, engages in two-way communication, listens, encourages, give recognition, and provides socio-emotional support to followers. The third style is call Laissez-faire or uninvolved leadership style, this is an employee-centered style in which the manager permits his or her employees to function within prescribed limits. A balanced leadership style is when the manager exhibits both task and people orientation. The third leadership perspective is Contingency; this is a perspective that proposes that effective leadership depends upon the degree of fit between the leader’s style and various factors in the particular situation. By nature, contingency theories are â€Å"if-then† theories; If the situation†¦. , Then†¦.. Depending upon the situation an appropriate leadership behavior will be used. There are three leadership theories that take a contingency perspective. First is Path-Goal Contingency theory. This theory proposes that leader effectiveness is based on an expectancy theory of motivation. This theory advises that the basic role of the leader is to clear the follower’s path to the goal. Research suggests that leaders can and should change their style to fit follower and workplace characteristics (contingencies). Leaders should use one of four behavior styles to help followers clarify the paths that lead them to work and personal goals. 4 behavior styles are; directive, supportive, participative and achievement-oriented. Second is Fiedler’s Contingency Theory, this theory suggests that high task and high people orientation is not best in all situations. Effective leadership depends on the match between the leader’s style and the degree of control he or she has in the situation. When control is high, situation is considered to be â€Å"favorable† and vice versa. Favorableness depends on three key factors or contingencies. Position power: the authority associated with the leader’s formal position in the organization. Leader-member relations: the quality of interpersonal relationships between a leader and the group members. Task structure: the degree of clarity, or ambiguity, in the work activities assigned to the group. The last theory is Leadership Substitutes Theory. This theory suggests that in some situations leaders can reduce the amount of leadership they exercise because it becomes unnecessary due to existing substitutes or neutralizers. Things that can substitute for leadership include; high skills of employees, team cohesiveness, formal controls. The fourth and last perspective is transformational. The theories mentioned so far have been, transactional leadership theories: a process of social exchange between followers and leaders that involves a number of reward based transactions. The transactional leader clarifies performance expectations, goals, and a path that will link achievement of the goals to rewards. Transformational leadership is leadership that inspires followers to share a vision, empowers them to achieve the vision, and provides the resources necessary for developing their personal potential. Transformational leaders serve as role models, support optimism, and mobilize commitment as well as focus on the followers needs for growth. Characteristics and Behaviors of Transformational Leaders Characteristics | Behaviors| Charisma (idealized influence): followers have complete faith in him/her| Articulates vision, mission| Inspirational motivation; inspires loyalty in the organization| Models the vision| Individualized consideration; gives personal attention to all members | Builds commitment to mission| Intellectual stimulation: enables followers to think about old problems in new ways| Demonstrates personal integrity | Evident of leadership is consist ently shown throughout The Hurt Locker from Staff Sergeant, Matt Thompson and First Class Sergeant, William James. At the beginning of the movie Matt Thompson lead the U. S Army Explosive Ordnance Disposal (EOD) in the Iraqi-American war. The trait perspective of leadership demonstrated by Matt Thompson includes Leadership motivation, honesty and integrity, and knowledge of the business. Matt seem to know what he is doing hence he is leading the team. He steps up when required; during the first scene of the movie Sergeant JT Sanborn, responsible for controlling the remote control vehicle is unable to execute his duties so Matt steps in and help out. Matt illustrates people oriented behavior because he tries to communicate with his partners. Matt Thompson is not confident enough and he doesn’t have that motivation and ambition, he tries to play it safe. During that scene Sanborn informs Matt that he is within the blast radius and Matt says â€Å"thanks for reminding me† in a sarcastic way which shows lack of confidence. Matt also lacks in leadership agility, as he was not able to make a wise and effective decision during a complex situation which cost him his life. First Class Sergeant, William James is Matt Thompson’s replacement. He is an extremely talented individual who shows outstanding leadership skills. After meeting Sanborn he gets emotional and tells him that he isn’t trying to replace Matt but just wants to do his best. This shows initiative and leadership motivation. James is very knowledgeable about his business which helps him to be self-confident. James has a balanced leadership style as he exhibits both task and people oriented behavior. James tells people what to do and how to do it, he ensures employees follow rules, and encourages employees to reach peak performance. As a Specialist, Owen Eldridge looks up to James. James recognizes this and tries his best to make sure Eldridge reaches his peak performance by telling him what to do and how to do it. During one of the scenes the bullet of a sniper rifle is jammed and James asks Eldridge to fix it. Unable to do so Eldridge asks James for help. James endangers himself to show Eldridge that he must spit on the bullet to remove to blood because the blood is causing the jam.